| abstract |
The present invention relates to modified 2' and 3'-nucleoside prodrugs for the treatment of flavivirus infections, describing 2' and/or 3'-nucleoside prodrugs of 1', 2', 3' or 4'-branched Prodrugs, and their pharmaceutically acceptable salts and derivatives. These prodrugs are used in the prophylaxis and treatment of Flaviviridae infections, including HCV infections, and other related conditions. Compounds and compositions of the prodrugs of the invention are described. Also provided are methods and uses comprising administering an effective amount of a prodrug of the invention, or a pharmaceutically acceptable salt or derivative thereof. These agents are optionally administered in combination or alternately with other antiviral agents to prevent or treat flavivirus infection and other related conditions. |