http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103319399-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 |
| filingDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103319399-B |
| titleOfInvention | The preparation method of Egelieting intermediate R-3-amino piperidine dihydrochloride |
| abstract | A kind of method that the main object of the present invention is to provide that route is brief, environmental protection, low cost prepare SYR-322 intermediate R 3 amino piperidine dihydrochloride.Reaction uses raceme compound 3 piperidine formamide cheap and easy to get as raw material, under 1 fluoronaphthalene, the hydrogen peroxide effect with fluoboric acid, the Hoffmann rearrangement reaction of similar amide occurs, obtains 3 amino piperidines of fewer than substrate carbon number 1.This reaction condition is simple, can carry out under room temperature；During simple to operate, it is easy to monitoring；Solvent for use is ethanol water mixture, cheap, environmental protection.Contracting carbon product 3 amino piperidine is acidified into salt through concentrated hydrochloric acid, and gained hydrochlorate, after the fractionation of D tartaric acid, becoming salt, obtains the double hydrochloric acid of target product R 3 amino piperidine, and chiral purity is high, and ee value is more than 99.5%.Reaction gross production rate is up to 89% 93%, and cost is relatively low, is especially suitable for industrialized great production. |
| priorityDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 141.