abstract |
The linker-drug intermediate of formula I is coupled to the antibody to form an antibody-drug conjugate, wherein the drug moiety is N-methylalanyl-maytansinoid. L is the following formula IA; E is the following formula IB or formula IC; n is 2, 3, 4, 5 or 6; m is 2, 3 or 4; and q is 0 or 1. |