http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288948-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2012-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103288948-B |
| titleOfInvention | Interferon alpha mutant and polyethylene glycol derivative thereof |
| abstract | The invention belongs to the field of biomedicine and relates to a consensus interferon cysteine mutant, a polyethylene glycol derivative of the consensus interferon cysteine mutant, a preparation method of the polyethylene glycol derivative, a pharmaceutical composition of the polyethylene glycol derivative, and application of the consensus interferon cysteine mutant and the polyethylene glycol derivative in preparation of drugs for treating viral diseases. According to the consensus interferon cysteine mutant, an amino acid at the 57-th position, counting from the N end, in an amino acid sequence of consensus interferon is mutated into cysteine; and the polyethylene glycol derivative of the consensus interferon cysteine mutant is obtained through connecting the consensus interferon cysteine mutant with a polyethylene glycol modifier, and the molecular weight of the polyethylene glycol modifier is 5-40 KDa. The consensus interferon cysteine mutant and the polyethylene glycol derivative of the consensus interferon cysteine mutant, disclosed by the invention, have higher biological activity, better pharmacological action and stability and more reliable safety. |
| priorityDate | 2012-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.