http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288911-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103288911-B |
| titleOfInvention | Toadpoison Medicine glycosylated derivative and method for making thereof and preparing the purposes in antitumor drug |
| abstract | The invention discloses Toadpoison Medicine glycosylated derivative and method for making thereof and preparing the purposes in antitumor drug, its structure of Toadpoison Medicine glycosylated derivative is such as formula shown in I or formula II, its synthetic method is: first Toadpoison Medicine is oxidized to keto-acid derivative with pyridinium chlorochromate hydrochloride, after carrying out nucleophilic addition with methoxamine hydrochloride again, slough a part water and generate oxime formula intermediate, oxime formula intermediate and TERTIARY BUTYL AMINE base borane hydrochloride mixture are reacted the aglycon generating α and β two kinds of configurations, finally the aglycon of these two kinds of configurations is generated Toadpoison Medicine glycosylated derivative with reducing sugar reaction respectively.The present invention, by Toadpoison Medicine is modified to its glycosylated derivative, can also increase water-soluble while keeping, enhancing anti-tumor activity.And prove through experiment in vitro, Toadpoison Medicine glycosylated derivative provided by the present invention, compared with its parent compound Toadpoison Medicine, reduces Normocellular toxic side effect. |
| priorityDate | 2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.