http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288801-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103288801-B |
| titleOfInvention | A kind of preparation method of high-purity esomeprazole sodium |
| abstract | The invention discloses a kind of preparation method of high-purity esomeprazole sodium: Omeprazole Sodium and D-(-)-diethyl tartrate, tetraisopropoxy titanium, triethylamine and L-(+)-amygdalic acid, inclusion resolution is carried out, through being separated to obtain Inclusion Complexes under suitable quantity of water exists; Inclusion Complexes through acetic acid ethyl dissolution, sodium bicarbonate aqueous solution washing, ethyl acetate layer behind ammoniacal liquor wash-out, slow adjust pH to 6 ~ 7 of glacial acetic acid with dichloromethane extraction, concentrated after esomeprazole crude free base; Crude product obtains esomeprazole free alkali sterling after silica gel adsorption, wash-out; High-purity esomeprazole sodium is obtained with after isopropyl ether crystallization after the methanol/ethanol-acetonitrile solution salify of sterling and sodium hydroxide.Easily occur titanium complex suspendible body when the invention solves inclusion resolution and split the difficult problem removed of ammonia complex difficulty of difficulty and titanium, can realize suitability for industrialized production, and industrial production cost is low, product purity is high, yield is high, does not produce obnoxious flavour. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023175090-A1 |
| priorityDate | 2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.