http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288671-B
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-14 |
filingDate | 2013-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103288671-B |
titleOfInvention | Synthetic method of (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride |
abstract | The invention provides a synthetic method of an intermediate (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride of an anti-hepatitis C new drug Telaprevir. The method comprises the following steps: carrying out (S)-N-benzyl-1-phenylethylamine addition and camphorsulfonyloxaziridine oxidation of a cheap raw material t-butyl sorbate to obtain chiral amine, carrying out t-butyl deprotection, carrying out condensation with cyclopropylamine to obtain amide, and carrying out hydrogenation reduction benzyl-deprotection to form hydrochloride in order to obtain (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride. The method has the advantages of less reaction steps, short synthetic period and strong applicability. |
priorityDate | 2013-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.