| abstract |
The invention describes a kind of pharmaceutical dosage form with active component site and time-controlled gastrointestinal release, relate to a kind of method of producing tablet, the predetermined variable position of this tablet in intestines and stomach discharges glucocorticoid, and described method comprises the position of determining in the intestines and stomach that need to send glucocorticoid; Form coating tablet, it has the sandwich layer that comprises glucocorticoid and inflatable auxiliary agent and does not expand also incorrosive inertia outer coatings layer; With suppress described tablet coating layer with the selected pressure that glucocorticoid is discharged in described precalculated position. |