http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103279689-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be2c55a9de09e08e3404c0a5a1ae4dc7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-12 |
| filingDate | 2013-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e1a26160c04e30fe65981de0adfb126 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_408fa76826949ce9683222ed526f0282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58398266bca2b6a41637eb29f4d0ce94 |
| publicationDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103279689-A |
| titleOfInvention | Secondary approach transformation method based on instruction of FK506 production bacterial strain wave chain streptomycete genome scale metabolic network model |
| abstract | The invention discloses a secondary approach transformation method based on an instruction of an FK506 production bacterial strain wave chain streptomycete genome scale metabolic network model. The model is based on annotation genes and physiology and biochemistry information. By comparing and analyzing the model with a streptomyces coelicolor genome, metabolic genes are found being highly conservative. Metabolic flux analysis is performed on a genome scale metabolic network, and therefore the model predicts a mutation bacterium secondary approach gene cluster transformation strategy for improving a production level. According to the secondary approach transformation method based on the instruction of the FK506 production bacterial strain wave chain streptomycete genome scale metabolic network model, the transformation method utilizes the genome scale metabolic network model to predict special structural genes in an FK506 bacterial strain secondary approach gene cluster, the production level of bacterial strains after transformation is improved by 20 percent to 90 percent, the special structural genes in the gene cluster are augmented to improve production capacity, and large application value is achieved in secondary approach rational transformation of microorganism immunosuppressor production bacterial strains. The high-efficiency and systematic method is provided for optimizing of the bacterial strains. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111223527-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111223527-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11208649-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11312951-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109943545-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11352621-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109943545-B |
| priorityDate | 2013-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.