http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103275978-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2009-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103275978-B |
| titleOfInvention | Modified small interfering RNA and preparation method thereof |
| abstract | The invention provides a modified small interfering RNA and preparation method thereof, which comprises a first fragment and a second fragment, and the first fragment and the second fragment form a double-chain area, and the first fragment comprises at least a continuous CA sequence or UG sequence, and the second fragment comprises at least one continuous UG sequence or CA sequence which is complementary to the CA sequence or UG sequence of the first fragment, and the CA sequence or UG sequence of the first fragment and the UG sequence or CA sequence of the second fragment form CA/UG locus, wherein, at least one nucleotide of the CA/UG locus is modified, thereby the stability of the modified small interfering RNA is higher than the unmodified small interfering RNA, and the first fragment is 5'-UGAACGUCACCGAGGAGAATT-3', and the second fragment is 3'-TTACUUGCAGUGGCUCCUCUU-5'. The invention increases the serum stability of the modified small interfering RNA, and reduces the latent cytotoxicity of the modified small interfering RNA and influence of modification to the biological activity of the small interfering RNA. |
| priorityDate | 2009-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.