| abstract |
The invention provides the ED-A antigen of the fibronectin relevant with the new vessel of metastases.The present invention relates to a kind of binding members, it, in conjunction with extra domain-A (ED-A) isotype of fibronectin, is used for the treatment of neoplasm metastasis.Especially, the present invention relates to a kind of binding members in conjunction with extra domain-A (ED-A) isotype of fibronectin and/or the ED-A of fibronectin, does wherein said antibody comprise: SEQ? ID? VH structural domain shown in NO:81, the amino acid except position 5 place of VH structural domain is leucine residue (L) instead of valine residue (V); And/or SEQ? ID? VL structural domain shown in NO:82, the amino acid except position 18 place of VL structural domain is arginine residues (R) instead of lysine residue (K). |