http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103269761-B

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3274
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3219
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3212
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-286
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-289
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-745
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-00
filingDate 2011-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-103269761-B
titleOfInvention affinity chromatography matrix
abstract The present invention relates to separate the method for protein that one or more contain immunoglobulin (Ig) from liquid. First described method comprises makes liquid and contains the isolation medium that is fixed on the part on holder and contact; By making the protein adsorption that contains immunoglobulin (Ig) on matrix with ligand interaction; Then clean the optional step of adsorbing the matrix that has the protein that contains immunoglobulin (Ig) on it; And by making matrix and the protein that discharges the eluent of protein and contain immunoglobulin (Ig) described in contacting to reclaim. Described method is the improvement of previous separation method, each part comprises one or more albumin A domains (E, D, A, B, C) or albumen Z or its functional variant, does at least one monomer have at the B domain corresponding to albumin A or albumen Z? the replacement of the locational asparagine of N28, and wherein said part provides the increase of wash-out pH compared with unsubstituted part.
priorityDate 2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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