| abstract |
The invention discloses the new ansamitocin derivant carrying linking group.Also disclose the method for synthesizing these new ansamitocin derivants and the method for their bindings with Cell binding agent.Ansamitocin derivant cell-binding agent conjugate can be used as therapeutic agent, and it with targeted cells and is Cytotoxic through specific delivery.These conjugates, compared with aforesaid reagent, demonstrate the curative effect greatly improved in animal tumor model. |