http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103265457-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-20 |
| filingDate | 2013-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103265457-B |
| titleOfInvention | A kind of synthetic method of (R)-4-aminophenethyl-(2-hydroxyl-2-styroyl)-t-butyl carbamate |
| abstract | The invention provides the synthetic method of one (R)-4-aminophenethyl-(2-hydroxyl-2-styroyl)-t-butyl carbamate, belong to technical field of medicine synthesis.It solve synthetic method product yield of the prior art low, the problem such as the loaded down with trivial details and environmental pollution for the treatment of step is serious.Synthesis step of the present invention comprises: first the hydroxyl oxygen on p-nitrophenyl ethanol is changed into aldehyde radical and obtain p-nitrophenyl acetaldehyde; The amino on (R)-2-amino-1-phenylethyl alcohol and the aldehyde radical dehydrating condensation on p-nitrophenyl acetaldehyde is made to reduce (R)-2-p-nitrophenyl ethylamino--1-phenylethyl alcohol again; With (Boc)n 2 o replaces the amino on (R)-2-p-nitrophenyl ethylamino--1-phenylethyl alcohol; Finally the nitroreduction on (R)-4-nitrophenethyl-(2-hydroxyl-2-styroyl)-t-butyl carbamate is become amino and obtain final product.Synthetic method production cost of the present invention is low, and product yield is high, and environmental pollution is little. |
| priorityDate | 2013-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.