http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103263388-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103263388-B |
| titleOfInvention | Stealthy vesicle of a kind of modified with folic acid norcantharidin and preparation method thereof |
| abstract | The present invention relates to stealthy vesicle of a kind of modified with folic acid norcantharidin and preparation method thereof.This vesicle is using poloxamer188-cholesterol cpds and FA-PEG-chol as main carriers material, and bag obtains surface hydrophilic after carrying norcantharidin and has the stealthy vesicle of modified with folic acid, and it is not containing free cholesterol.The envelop rate of this vesicle is (52.30 ± 2.16) %, and mean diameter is (100.87 ± 0.23) nm, zeta current potential is-25.96mV, and tablets in vitro is significantly slow in crude drug, the release t in simulation normal structure pH7.4 environmentn 1/2 be 1.98 times in simulation tumor cell pH5.0 environment, slow releasing function significantly and be conducive to discharging in target cell.And this vesicle can significantly strengthen the growth inhibition ratio of tumor cell and take the photograph dose, produce the active targeting effect to tumor cell at molecular level, thus improve efficacy of drugs, be conducive to high-efficiency low-toxicity Therapeutic cancer. |
| priorityDate | 2012-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.