| abstract |
Use variation disclosed in Fc district can build monoclonal antibody and other molecule containing Fc, disclosed in described Fc district, variation causes increases the resistance of the protease that host and pathogen derive, and demonstrate with Fc γ acceptor interaction and the Cytotoxic ability that instructs of initial complement, as confirmed by functional examination method.Molecule containing Fc is used for the treatment of host's function that wherein FcR drives and facilitates active disease and disease. |