| abstract |
The present invention relates to the vaccinia ankara virus of recombinant modified, it comprises the allogeneic dna sequence inserted in the genomic intergenic region of described MVA, wherein, described IGR between genomic two adjacent open reading frames of this MVA or described IGR be positioned at the side of genomic two adjacent open reading frames of this MVA, and wherein said ORF corresponds to conservative gene, and wherein said two adjacent ORF by way of example or its corresponding manner be selected from by the 044-045 in (using the nomenclature of CDC/ A Kamu bass) other vaccinia virus strain, 049-050, 050-051, 058-059, 064-065, 065-066, 069-070, 070-071, 071-072, 072-073, 073-074, 074-075, 075-076, 076-077, 077-078, 078-079, 081-082, 085-086, 086-087, 089-090, 092-093, 093-094, 095-096, 097-098, 100-101, 101-102, 102-103, 104-105, 108-109, 113-114, 114-115, 118-119, 121-122, 122-123, 123-124, 127-128, 128-129, 129-130, 130-131, 131-132, 132-133, 133-134, 134-135, 135-136, the group that 141-142 and 142-143 forms. |