http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103254196-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_449ee1f69302de87bfd60c4a53c42b1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41cfacda69cf945e5eb2d1a004344777 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2013-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f2d8bfa3107afc14c8bc190730d6187 |
| publicationDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103254196-A |
| titleOfInvention | The preparation method of pemetrexed diacid |
| abstract | The present invention discloses a preparation method of pemetrexed diacid (I), which comprises: 4-[(4,4-dimethoxy-3-hydroxy)butyl)benzoic acid (II) and L-glutamic acid diester (III) undergoes a condensation reaction to generate 4-[(4,4-dimethoxy-3-hydroxyl) butyl]benzoyl-L-glutamic acid diester (IV); compound (IV) obtain 4-[(4-oxo-3-halo) butyl] benzoyl-L-glutamic acid diester (V) through halogenation and acidolysis; Intermediate (V) and 2 , 4-diamino-6-hydroxypyrimidine (VI) ring combined with alkaline hydrolysis to obtain pemetrexed dioic acid (I). The preparation method has easy-to-obtain raw materials, simple process, economy and environmental protection, and is suitable for industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114539353-A |
| priorityDate | 2013-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.