http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103254153-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b70357e4586c7a42a06d5d0d60869ca4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 |
| filingDate | 2013-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_896d64af23cd488ab026ff4f843734a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89a50abad79ba1a51eaaec0e9b087d2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9af55f9224159567f6b44f16ce19db08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_670d9ddba18711dbd0c9eb07bc041f4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8e0eba56b59db797afc657d5b3ad006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9fd1a56be6271667d27afb0c6c80355 |
| publicationDate | 2014-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103254153-B |
| titleOfInvention | Preparation method of high-purity 1-[2-(2-hydroxyethoxy)ethyl]piperazine |
| abstract | The invention discloses a preparation method of high-purity 1-[2-(2-hydroxyethoxy)ethyl]piperazine, which comprises the following preparation steps: 1) reacting piperazine and piperazine dihydrochloride in solvent to prepare piperazine monohydrochloride; 2) reacting the piperazine monohydrochloride and 2-(2-chloroethoxy)ethanol in solvent; 3) after the reaction is finished, filtering to recover piperazine dihydrochloride, and drying for repeated use; 4) evaporating the filtrate to remove the solvent, thus obtaining a high-purity 1-[2-(2-hydroxyethoxy)ethyl]piperazine crude product; and 5) performing vacuum reduced pressure rectification on the 1-[2-(2-hydroxyethoxy)ethyl]piperazine crude product, and collecting the 1-[2-(2-hydroxyethoxy)ethyl]piperazine fraction to obtain the high-purity product. The invention effectively solves the problem that the disubstituted compound impurity content is high and improves the product purity; and the cost of the raw materials is low, the process cost is greatly lowered, and the process is greener and more environment-friendly, thereby ensuring that the preparation method is suitable for industrial production. |
| priorityDate | 2013-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.