http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103254074-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f4662f8e70784813cee3083274c4ec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e3041781d58f04095650f62530800996 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_064582a4158828e7b04e5de88e74ebea http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_181032b4df9fa32aacd8058b439d6eae http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bf1926e4323da5309474cf104ee70a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9775c71f682acc9ea7dde189ac48e551 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a2082cb9165f98765dee006b116fe53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59155c12a6c6d12cc2517029042fdfb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73f908e6d7e388817f3a203a46716e29 |
| publicationDate | 2015-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103254074-B |
| titleOfInvention | Preparation method of ethyl difluoroacetate and intermediate thereof |
| abstract | The invention discloses a preparation method of ethyl difluoroacetate and an intermediate thereof. The preparation method comprises the following steps of: dropwise adding a mixed solution of a compound I and ethanol to concentrated sulfuric acid at a temperature in the range from 90 to 110 DEG C for reacting, and simultaneously, distilling out generated ethyl difluoroacetate in the dropwise adding process, wherein each of R1 and R2 independently represents phenyl or C1-3 linear-chain or branch-chain alkyl, respectively and when each of R1 and R2 independently is the C1-3 linear-chain or branch-chain alkyl, R1 and R2 are different; and the preparation of the compound I comprises the steps of mixing a compound II with potassium fluoride for reacting in the presence of a catalyst namely a calixarene compound in a solvent; and the preparation of the intermediate compound II comprises the steps of mixing a compound III with a solvent, and dropwise adding dichloroacetyl chloride at a temperature in the range from -15 to 150 DEG C for reacting. The preparation method disclosed by the invention employs dichloroacetyl chloride and secondary amine as starting raw materials, and is simple and convenient in production process, low in quantity of three wastes, high in yield and suitable for industrial production. |
| priorityDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.