http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103251600-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b75a05785dbfd86d27a87ddcdc5a524 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e75f4164340722f8a6bb569e7a925062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7917f416db4db361fd386e3c94c8f53e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_395f198ad2ad20050500a2736dfd044a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26e0071d267bdef6965d70ba6a05cee7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1717806d325e17bf908042f4bb6e1164 |
| publicationDate | 2015-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103251600-B |
| titleOfInvention | Antitumor application of 2-amino-4-(3'-cyano-4'-pyrrolidyl)phenylpyrimidine compound |
| abstract | The invention discloses an antitumor application of a 2-amino-4-(3'-cyano-4'-pyrrolidyl)phenylpyrimidine compound. Researches show that the compound is capable of doubly inhibiting TBK1 (TANK-binding kinase-1) and IKKi in a targeted manner, and has better proliferation inhibition potentials in a plurality of tumor cell strains cultured in vitro; and experiments prove that 2-amino-4-(3'-cyano-4'-pyrrolidyl)phenylpyrimidine is capable of down-regulating protein expression levels of CyclinD1, p-AKT and p-CYLD and inducing tumor cell apoptosis. Animal model tests show that the compound remarkably inhibits the growth of mouse tumors and the tumor angiogenesis, has no obvious toxic or side effect, has better anti-tumor effect and broad application prospect, and can be used for developing an anti-tumor medicament. |
| priorityDate | 2013-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.