http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103242432-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103242432-B |
| titleOfInvention | By the method for hydrogen diphosphite intermediate synthesis phosphorus ammonia rice ketone |
| abstract | By a method for hydrogen diphosphite intermediate synthesis phosphorus ammonia rice ketone, comprise the following steps: utilize α-L-triacetyl rhamnosyl, the sub-phosphoryl chloride of benzyloxy diisopropylaminoethyl generates phosphoramidite intermediate in the basic conditions; α-L-rhamanopyranosyl-1-hydrogen diphosphite intermediate is obtained through weak acid catalytic hydrolysis; Utilize oxidative coupling method will be obtained by reacting phosphamide precursor with light tone dipeptides benzyl ester nitrogen end; Finally " one kettle way " hydrogenation and deacetylation remove whole protecting groups of phosphamide precursor, obtain high purity phosphorus ammonia rice ketone through sephadex chromatography purifying.The present invention is by carrying out design and optimization to the protecting group of L-rhamnosyl, phosphitylation agent and light tone dipeptides three synthesis fragment; farthest simplify the step of product precursor deprotection; and utilize the method for New Hydrogen diphosphite intermediate and oxidative coupling greatly to improve the productive rate of target product, for the chemosynthesis of phosphorus ammonia rice ketone establishes a kind of new method. |
| priorityDate | 2013-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 145.