http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103242231-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103242231-B |
| titleOfInvention | Quinoline derivatives and preparation method thereof and application |
| abstract | The present invention relates to the quinoline of replacement new shown in formula I, its pharmaceutically acceptable acid additive salt.The compounds of this invention is defined as follows especially: wherein Rn 1 and Rn 2 independently be methyl, ethyl or benzyl, or Rn 1 and Rn 2 the N connected with them can together with form 4-methyl piperidine base or morpholinyl, n=1 or 2.The invention still further relates to the method preparing the compounds of this invention.To show in such compound on tumor cell paste through pharmacological activity screening experiment, externally have obvious anti-proliferative effect, part of compounds has obvious antitumor activity.Such as lung cancer, liver cancer, mammary cancer and carcinoma of the pancreas.Particularly to the inhibitory rate 46.7% of carcinoma of the pancreas PANC-1. |
| priorityDate | 2013-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.