| abstract |
The invention discloses a kind of 2,6-diketone-piperazine (piperidines) analog derivative and application thereof, described derivative can be applicable to preparation prevention or treatment central nervous system disease medicine.Animal test results shows, and induce ED50 in two animal models of the climbing of high reactivity and apomorphine induction less at MK-801, effect is stronger, and ED50 is larger in the cataleptic model of animal, and therapeutic index is larger.Described derivative is for having the compound or its salt of general formula (I): |