| abstract |
Provided is a novel therapeutic agent for myeloma. A pyrazole compound represented by general formula (1), a tautomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a therapeutic agent for multiple myeloma containing the aforementioned as an active ingredient, wherien R<1> represents a C1-C6 alkyl, an R<17>-substituted C1-C6 alkyl, a C1-C6 haloalkyl, a phenyl, or a phenyl substituted by a number (a) of R<11>, or the like; R<2> represents a hydrogen atom, a C1-C6 alkyl, a phenyl, or a phenyl optionally substituted by a number (e) of R<21>, or the like; R<3> represents a hydrogen atom or the like; x represents a single bond or -(CR<6>R<7>)n-; R<4> and R<5> each independently represent a C1-C6 alkyl or the like; R<6> and R<7> represent a hydrogen atom or a C1-C6 alkyl; and R<8> represents a phenyl, or a phenyl optionally substituted by a number (k) of R<81>, or the like. |