http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103232437-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2013-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103232437-B |
| titleOfInvention | The preparation method of rabeprazole sodium crystal type compound |
| abstract | The present invention relates to medicine preparation field, be specifically related to a kind of preparation method of rabeprazole sodium crystal type compound, obtain rabeprazole thioether with raw material 2-mercaptobenzimidazole and 2-chloromethyl-3-methyl-4-methoxy propoxy pyridine hydrochloride through condensation reaction, rabeprazole thioether obtains rabeprazole after oxidizing reaction, and rabeprazole and sodium hydroxide obtain Sodium rabeprazole through salt-forming reaction.The present invention selects the raw material of low, the easy purchase of cost, and trial-product related substance and content under high temperature, super-humid conditions is substantially unchanged, article stable in properties; Overall low cost of manufacture; Strict temperature control in step, by product is few, and yield is high, nontoxicity.The present invention also has advantage with short production cycle, further increases production efficiency. |
| priorityDate | 2013-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.