http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103232416-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52f52141c5ab8e0754fd3f9ddf67eab2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 2013-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12dcdced349f14fadf4456299339977c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0711ad6f39918cfc7dcb01df35fd1b01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c99ca4ff2f11b5c9483d1e233159be45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed9d7c6fc0553248f6144f515e83c275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dd41f2b2d40b37d7c0a97ffdf25381e |
| publicationDate | 2015-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103232416-B |
| titleOfInvention | Method for separating and purifying 10-deacetylated paclitaxel (10-DAP) |
| abstract | The invention discloses a method for separating and purifying 10-deacetylated paclitaxel (10-DAP), which is characterized by comprising the following steps: reacting a raw material containing 10-DAP with a weakly polar or nonpolar hydroxy protective agent in an organic solvent reaction system; carrying out normal-phase silica gel column chromatography on the reaction product; separating by a ternary gradient elution method to obtain a high-purity C(2')-position hydroxy-protected 10-DAP; and removing the hydroxy protecting group to obtain the 10-DAP. The whole method is simple to operate, is mild, controllable and efficient, and is suitable for large-scale preparation of the 10-DAP with the purity of greater than 99%. |
| priorityDate | 2013-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.