http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103232368-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-14 |
| filingDate | 2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103232368-B |
| titleOfInvention | A kind of synthetic method of (R)-4-nitrophenethyl-(2-hydroxyl-2-styroyl)-t-butyl carbamate |
| abstract | The invention provides the synthetic method of one (R)-4-nitrophenethyl-(2-hydroxyl-2-styroyl)-t-butyl carbamate, belong to technical field of medicine synthesis.It solve the synthetic method product yield synthesizing (R)-4-nitrophenethyl-(2-hydroxyl-2-styroyl)-t-butyl carbamate in prior art low, need column chromatography for separation, be not suitable for the problem of large-scale industrial production.This synthesis step comprises: 1) hydroxyl oxygen on equal amido phenenyl alcohol is changed into aldehyde radical and obtain p-nitrophenyl acetaldehyde; 2) (R)-2-amino-1-phenylethyl alcohol reduction amination is obtained (R)-2-p-nitrophenyl ethylamino--1-phenylethyl alcohol; 3) with (Boc)n 2 o replaces amino the final product on (R)-2-p-nitrophenyl ethylamino--1-phenylethyl alcohol.Synthetic method of the present invention becomes to produce cost low, and the finished product yield is high, is applicable to large-scale industrial production. |
| priorityDate | 2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.