http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103232345-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb02d0cd706bab8b655297e981f8a508 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-32 |
| filingDate | 2013-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95784855a60492891b05b4d34915474a |
| publicationDate | 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103232345-B |
| titleOfInvention | Synthesis method of 8-hydroxyl ethyl caprylate |
| abstract | The invention relates to the synthesis technical field of medical intermediates and discloses a synthesis method of 8-hydroxyl ethyl caprylate. The synthesis method comprises the following steps of: dissolving 6-bromohexanol and diethyl malonate in an azeotropic organic solvent, heating to have reaction under alkaline catalysis to generate an intermediate which is 2-(6-hydroxyl hexyl) diethyl malonate, wherein the molar ratio of 6-bromohexanol to diethyl malonate to alkali is 1:0.95-1.05:1.37-2.73; and dissolving the intermediate in a polar aprotic solvent and water, heating to having reaction under catalytic effect of sodium halide to generate 8-hydroxyl ethyl caprylate, wherein the molar ratio of the intermediate to sodium halide is 1:1-3. According to the technical scheme provided by the invention, the process line is simple and the cost of raw materials is low; therefore and the method is favorable to industrial production. |
| priorityDate | 2013-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.