http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103230369-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate | 2013-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103230369-B |
| titleOfInvention | A kind of nucleic acid aptamer nanometer formulation for Transforming growth factor beta type Ⅱreceptor and preparation method thereof |
| abstract | The invention provides a kind of nucleic acid aptamer nanometer formulation for Transforming growth factor beta type Ⅱreceptor.This nucleic acid aptamer nanometer formulation is the spherical particle be made up of chitosan and nucleic acid aptamer, chitosan parcel nucleic acid aptamer, and wherein the mol ratio of chitosan and nucleic acid aptamer is greater than 20: 1; The particle diameter of described nucleic acid aptamer nanometer formulation is 100 ~ 300nm, and current potential is+4 ~+28mV; Described nucleic acid aptamer is Seq58.The present invention also provides the preparation method of described nucleic acid aptamer nanometer formulation.The nucleic acid aptamer nanometer formulation that the present invention is directed to Transforming growth factor beta type Ⅱreceptor can suppress TGF-β to be combined with its receptor T β R II competitively, and there is good serum stability and slow-releasing, be expected to the novel biological engineering medicine becoming glaucoma filtering surgery cicatrization and prevent and treat other fibrillation related diseases. |
| priorityDate | 2013-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.