http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103214424-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9238983399fe26f6cf6879996147c7e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-24 |
| filingDate | 2013-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b688dcfa55a5879f14a31e709086e09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ab0f9ee233672c11335d8fce8920801 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b55ecd7f45bfc0aab4d5505fdf377e2a |
| publicationDate | 2015-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103214424-B |
| titleOfInvention | Synthesis method of pyrazine methylamine derivative |
| abstract | The invention discloses a synthesis method of a pyrazine methylamine derivative. The method comprises the following steps: in a solvent, oxidizing a methyl pyrazine derivative by using ceric ammonium nitrate at a temperature of 20-40 DEG C so as to obtain a aldehyde pyrazine derivative; and under the action of an organic alkali, reacting the aldehyde pyrazine derivative with hydroxylamine hydrochloride at room temperature, reducing a reaction intermediate by using a reducing agent, and carrying out separation on the obtained product so as to obtain the pyrazine methylamine derivative. Compared with the existing synthesis methods, the synthesis method disclosed by the invention is few in steps and high in product yield; the yields of two steps can be respectively above 46%, reactants are purified from reaction liquid more easily, and the reaction temperature can be below 40 DEG C; the synthesis method has no special requirements on equipment; and the synthesis method is simpler in operation, stable in intermediate, and suitable for large-scale production. |
| priorityDate | 2013-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.