http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103212086-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103212086-B |
| titleOfInvention | A kind of high drug load Podophyllum emodi var chinense nano-prodrug and its preparation method and application |
| abstract | The present invention discloses the prodrug of a kind of podophyllotoxin (POD) derivative, this prodrug is formed by the imines key covalent attachment of acid-sensitive by drug molecule and hydrophilic short chain polyalkylene glycol (PEG), wherein, described drug molecule is derivative amino Podophyllum emodi var chinense (NPOD) of podophyllotoxin, it takes medicine amount can reach more than 35%, and this prodrug can form the micella with nanostructure in aqueous by the mode of self-assembly. The invention also discloses this self-assembly prodrug micella as new pharmaceutical carrier, for load such as the application of class hydrophobic drugs such as taxol, it is achieved that the synergistic therapeutic action of medicine. The present invention has that preparation method is simple, environmental protection, economy, possess bigger using value at biomedicine field. |
| priorityDate | 2013-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.