http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103211797-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103211797-B |
| titleOfInvention | Verapamil hydrochloride film-controlled slow-release micro pill capsule |
| abstract | The present invention relates to a kind of verapamil hydrochloride film-controlled slow-release micro pill capsule, the sustained release clothing film of its micropill is using Eurdragit NE30D as filmogen, sodium carboxymethyl starch containing high-expansion in capsule core, and the conventional excipient of pharmaceutically acceptable sustained release pellet, excipient preferably microcrystalline cellulose, wherein, the percentage that sodium carboxymethyl starch accounts for capsule core weight in capsule core is 5~20%.Sustained release clothing film includes Eurdragit NE 30D and antiplastering aid talcum powder, and its ratio is preferably Eurdragit NE 30D: talcum powder=30: 4, coating weight gain is preferably 19~35%.Due to containing the capsule core with the sodium carboxymethyl starch for meeting water high-expansion, can substantially be expanded after water suction, sustained release clothing film is caused to be stretched, thickness is thinning, and the aperture of permeable micropore becomes big, and permeability improves, the permeability that compensate for the aging generation of film declines, so that middle and later periods rate of release substantially constant, latter stage residual is small, can before the deadline remain the release performance of stabilization. |
| priorityDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.