| abstract |
The invention relates to the technical field of biomedicine, and in particular relates to a new application of partial metabolite of pentapeptide in preparation of a myocardial ischemia resistant product. The amino acid sequence of the small peptide is shown as Seq No.2, No.3, No.4, No.5, No.6 and No.7. Through pharmacological experiments of acute rat myocardial ischemia and damage models, the small peptide and the metabolite thereof can remarkably reduce the range of rat myocardial damage and myocardial infarction caused by myocardial ischemia, reduce the content of lactic dehydrogenase and creatine kinase in myocardial ischemia rat serum and have the function of preventing and treating the myocardial ischemia, so the small peptide and the metabolite thereof can be used for preparing a medicament for preventing and treating the myocardial ischemia. |