http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103194511-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ee33b0e3e7398cf6fc957eeee59d510 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-64 |
| filingDate | 2013-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9a8fc83f656989709303ddba05b0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97fe993c42c8f04f22b9d72035580d28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4231ea184931b60a505cde6e25d6dda1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e34f4e9e8dde39a3d28bb22066adb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02c09a441c619a8c73974c9b0b18372b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3bc58e616c0a2064ecd0b905ce5be42 |
| publicationDate | 2014-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103194511-B |
| titleOfInvention | Method of lipase-catalyzed synthesis of fatty acid ester of clindamycin |
| abstract | The invention discloses a method of lipase-catalyzed synthesis of fatty acid ester of clindamycin. The method comprises: reacting the clindamycin with fatty acid and/or fatty acid ester for 0.05-72 hours under 20-80 DEG C in the presence of a catalysis effect of the lipase, separating and purifying the reaction solution to obtain the fatty acid ester of clindamycin, wherein a mole ratio of the clindamycin with the fatty acid and/or the fatty acid ester is 1 : 0.1 to 1 : 10, and an amount of the lipase is 0.01-10 times of a mass of the clindamycin. The method realizes enzymatic synthesis of the fatty acid ester of the clindamycin for the first time, prevents protective and de-protective processes for 3,4-hydroxy of the clindamycin during a chemical synthesis of the product, reduces technological process, and has characteristics of high catalytic efficiency, good selectivity and good stability. |
| priorityDate | 2013-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 230.