http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103193844-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 |
| filingDate | 2013-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103193844-B |
| titleOfInvention | The synthetic method of key intermediate of fluticasone propionate |
| abstract | The invention provides a kind of synthetic method of key intermediate of fluticasone propionate; the strategy of cyclic orthoesters (I) open loop is used efficiently to introduce the propionyl protecting group of 17 hydroxyls, construction of strategy 20 carboxylic acids of the Periodic acid original position open loop for the treatment of different things alike and oxidation open loop.Described intermediate (I) has following structural formula:n described key intermediate of fluticasone propionate (II) has following structural formula:n this technique solves the problem of 17 crowded hydroxyl selective protections of space, and step does not increase, and operation and cost are all improved. |
| priorityDate | 2013-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.