http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103193735-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ced975bd5ff4f8b91215b67c40b06430 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 2013-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b6e453ce88d3ac39abdcf9a1d98eced http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c7bd14adb3d62ab033da653df98903 |
| publicationDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103193735-B |
| titleOfInvention | Extraction method for taxus chinensis taxol activity extract |
| abstract | The invention relates to an extraction method for a taxus chinensis taxol activity extract. The extraction method comprises the steps of: firstly, crushing taxus chinensis branches and leaves into 20-50 meshes, and adding 3-5 times of a petroleum ether and normal hexane mixture, wherein the ratio of the petroleum ether to normal hexane is (2-3):1; standing at 0-5 DEG C for 10-12 hours, and filtering to obtain filter residue; and then digesting and finally performing silica-gel separation. According to the technique, by adopting low-temperature digestion, as well as digestion with different concentration gradients of methanol, the taxol can be well protected, so as not to be transformed in the separation process, and as a biological macromolecule substance, the taxol is easily degraded or isomerized to produce other taxanes substances under the influences of conditions such as temperature, organic solvent, acid, and alkaline. For example, the taxol can be degraded into bacctain III or have epitope isomerization to produce 7-epi-taxol under the strong acid or weak alkaline environment condition; and the taxol can also have degradation reaction at a higher temperature to produce corresponding micromolecular substances. With the technique, the yield of the taxol can be greatly improved, and the purity of the product is high. |
| priorityDate | 2013-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.