| abstract |
The invention discloses a sulfonamide compound, a pharmaceutical composition, a preparation method and an application thereof. The sulfonamide compound of the present invention can be used as a small-molecule tubulin inhibitor, which not only has an anti-microtubule effect in vitro, but also induces apoptosis of tumor cells, and has obvious inhibitory effect on multi-drug resistant cells. in vivo oral antitumor activity. In addition, this type of compound has the advantages of small molecular weight, simple synthesis, and less toxic and side effects. The present invention also provides a pharmaceutical composition containing the sulfonamide compound and its pharmaceutically acceptable salt as an active ingredient. |