http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103193657-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-50 |
| filingDate | 2013-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103193657-B |
| titleOfInvention | A kind of method of synthesizing ezogabine intermediate |
| abstract | The invention discloses the intermediate 4-(4-fluorobenzylamino of ezogabine (formula A)) synthetic method of-1,2-phenylenediamine (formula C).n the present invention for raw material, obtains intermediate 4-(4-fluorobenzylamino through nucleophilic addition(Adn)/dehydration, reduction two-step reaction one kettle way with 2-nitro-Isosorbide-5-Nitrae-phenylenediamine and p-Fluorobenzenecarboxaldehyde)-2-N-methyl-p-nitroaniline (formula B).Ezogabine intermediate 4-(4-fluorobenzylamino is synthesized with ammonium sulfate-sodium borohydride systems reduction B)-1,2-phenylenediamine (formula C).Reaction has that the time is short, aftertreatment is easy, yield advantages of higher. |
| priorityDate | 2013-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.