http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103193628-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-84 |
| filingDate | 2013-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103193628-B |
| titleOfInvention | Alpha-ketophenylalanine calcium preparation method |
| abstract | The invention discloses an alpha-ketophenylalanine calcium preparation method. The alpha-ketophenylalanine calcium preparation method comprises the following steps of: mixing glycolylurea, medium strong base and water, adding benzaldehyde, reacting to separate out isobutylidene glycolylurea, dropwise adding strong base liquor, stirring and heating till reflowing, reacting, adjusting the pH, extracting, adding alkali to an organic phase, uniformly mixing, adding water for extraction, adding alcohol to a water phase, dropwise adding a calcium chloride aqueous solution for heat preservation and reaction, filtering and washing to prepare the alpha-ketophenylalanine calcium. According to the alpha-ketophenylalanine calcium preparation method, after condensation reaction is ended, the isobutylidene glycolylurea is not separated and directly hydrolyzed, the utilization rate of equipment can be increased by 30%, the operation is simple, extracted alpha-ketophenylalanine does not need to be concentrated, the decomposition of the alpha-ketophenylalanine can be avoided during concentration, the alpha-ketophenylalanine is directly converted into ammonium salt in the organic phase, and then the ammonium salt is converted into calcium salt in the water phase, reaction conditions are mild, the purity is high, the total impurity is less than or equal to 5%, the cost is low, few wastewater is generated, the pollution to the environment is little, the raw materials are easy to obtain, the product quality is stable, the reaction yield of the method is 10% higher than that of the prior art, qualified products are directly obtained through salt forming reaction, and the multiple recrystallizaiton is avoided; and the alpha-ketophenylalanine calcium preparation method has no special requirements on equipment and is suitable for industrial production. |
| priorityDate | 2013-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.