http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103191412-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-16 |
| filingDate | 2013-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103191412-B |
| titleOfInvention | PA200 and acetylation mediate core histones to degrade by proteasome |
| abstract | The invention discloses PA200 albumen to prepare the application in product；The function of the product is at least one of following (1) to (4): (1) combining acetylated protein matter；(2) promote the degradation of acetylated protein matter；(3) reparation of body cell DNA damage is participated in；(4) spermiogenesis tail is participated in.The present invention achieves breakthrough at following four aspects: (1) finding the mechanism that the degradation of acetylation regulation histone, spermatogenesis and DNA are repaired.(2) acetylation is disclosed, rather than ubiquitination, mediation histone are degraded by PA200/Blm10 proteasome.(3) discovery is novel contains PA200, the testis specific proteasome of α 4s, and discloses first kind physiologic substrate of the core histones as these proteasomes.(4) announcement histon deacetylase (HDAC) inhibitor promotes histone degradation by DNA double chain fracture induction, being mediated by acetylation, enhances cell to the sensibility of DNA damage, easily causes cell death. |
| priorityDate | 2013-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 356.