| abstract |
The invention relates to a preparation method of a medical raw material 7β-amino-7α-methoxy-3-cephem compound. Most of the existing methods have the problems of many steps and low yield. The preparation method of the 7β-amino-7α-methoxy-3-cephem compound of the present invention is characterized in that the β-lactam compound is used as a raw material, and it is mixed with bis(trichloromethyl)carbonate in the presence of an organic base Carry out the reaction to generate chloroimino-β-lactam compound, then add methanol for alcoholysis to generate 7β-amino-7α-methoxy-3-cephem compound. The reaction conditions of the present invention are mild and easy to control, the yield is high, the reaction does not produce 7α-amino-7β-methoxy-3-cephem compound isomers, the separation is easy, and 7β-amino-7α-methoxy with extremely high purity is obtained Base-3-cephem compound products. |