http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103183673-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103183673-B |
| titleOfInvention | The synthetic method of (S, S)-2,8-diazabicyclo [4,3,0] nonane |
| abstract | The invention discloses the preparation method of a kind of compound 1 (S, S) 2,8 diazabicyclo [4,3,0] nonane.In existing method, all use and finally carry out chiral separation, all fail to control chirality during early stage synthesis main ring, cause last total recovery the most on the low side, had a strong impact on the synthesis cost of (S, S) 2,8 diazabicyclo [4,3,0] nonane.In organic solvent, in the presence of organic amine, benzsulfamide, under the conditions of 0 30 DEG C, prepares compound 5 with acrolein reaction to the present inventionï¼›Compound 5, in the presence of organic amine and chiral catalyst, carries out D A additive reaction with compound 4, prepares compound 6ï¼›Compound 6 is by catalytic hydrogenation, carbonyl reduction, and Deprotection, chiral separation purify the most in acid condition.The present invention fundamentally solves prior art final products and causes the problem that total recovery is low due to chiral separation, and then improves the yield of product. |
| priorityDate | 2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.