http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103183635-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3eafe76dc6ae4cd73fb83b4d1496930d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 |
| filingDate | 2013-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f9fafa883110be04e97701105e45470 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b46f2907db8eecbe8f7822e0025a612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30e79113ec727d24318f94a92426e283 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ca6d69b21852164f44157dc7554ae0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9af189bd9752f2d5b7aca4d0ad3eb4b6 |
| publicationDate | 2014-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103183635-B |
| titleOfInvention | New process for synthetizing 3-(pyridin-2-ylamino) ethyl propionate |
| abstract | The invention discloses a new process for synthetizing 3-(pyridin-2-ylamino) ethyl propionate. The process comprises the steps as follows: 2-chloropyridine-N-oxide is taken as a starting material; under the existence of a solvent and inorganic base, the 2-chloropyridine-N-oxide reacts with 3-aminopropionic acid, so that 3-(pyridin-2-ylamino) propionic acid N-oxide is produced; most of the solvent is decompressed, concentrated and removed, the PH value is adjusted to 6.5-8 by hydrochloric acid, then ethanol is added, most of sodium chloride is filtered and removed, and a filtrate is concentrated to be dry, so that a compound 1 is obtained, and the purity is more than 95% (HPLC(high performance liquid chromatography));and the compound 1 is mixed with ethanol; and an additive is added, an esterification reaction occurs, inorganic base is added after the reaction, the mixture is stirred for a period of time and then filtered, and finally the filtrate directly catalyzes hydrogen gas and the mixture is reduced, so that the 3-(pyridin-2-ylamino) ethyl propionate is obtained. According to the new process, reaction raw materials are low in cost, the reaction yield of each step is higher, the operation is simple and convenient, pollution is reduced, a column chromatography is not required, and industrial amplification is facilitated. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104910066-A |
| priorityDate | 2013-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.