| abstract |
The invention discloses an application of compounds in treatment of osteoporosis in the field of medicaments, wherein the compounds have a structural general formula of 6-[indole-3-methylene]-1,3,4-thiadiazolo[3,2-a] pyrimidine. The compounds are excitomotors for parathormone type I receptors (PTH1R), and can improve the activity of osteoplasts, promote bone formation and increase the bone density. The variable parts of the structural general formula (1) are as defined in the specification. |