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filingDate 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41ed848069a89b39e42109fc38e4dcd0
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publicationDate 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-103153927-A
titleOfInvention Fused cyclooctynes and their applications in metal-free click reactions
abstract The present invention relates to fused cyclooctyne compounds and processes for their preparation. The invention also relates to conjugates wherein the fused cyclooctyne compounds of the invention are conjugated to labels, and the invention relates to the bioorthogonal labeling, imaging and/or modification of these conjugates on target molecules (e.g. surface modifications). The invention also relates to methods for the modification of target molecules, wherein the conjugates of the invention are reacted with 1,3-dipole or 1,3-(hetero)diene-containing compounds.
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priorityDate 2010-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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