abstract |
The present invention relates to certain oxazole derivatives useful as modulators of fatty acid amide hydrolase (FAAH) and as FAAH imaging agents. The invention also relates to pharmaceutical formulations comprising these compounds as active ingredients and the use of said compounds and formulations in the treatment of certain conditions including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, herpetic neuralgia, skeletal myalgia and fibromyalgia, and use in acute pain, migraine, sleep disorders, Alzheimer's disease, and Parkinson's disease. |