http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103145977-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-48 |
| filingDate | 2013-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103145977-B |
| titleOfInvention | A kind of preparation method of mPEG2000-DSPE sodium salt |
| abstract | The invention discloses a kind of preparation method of mPEG2000-DSPE sodium salt, Compound I and Compound II per are obtained by reacting compound III, compound VI I and thanomin are obtained by reacting compound IV, then compound III and compound IV are obtained by reacting compound V, the benzyl protecting group in palladium carbon and ammonium carbonate strip compound V is used to obtain compound VI, final compound VI and alkali reaction and get final product; This law processing step is less, and preparing compound V one pot reaction by Compound I can complete, and technological operation is easy, is easy to suitability for industrialized production; Avoid and use DSPE to be intermediate, thus decrease the generation of impurity, improve overall yield; Reaction preference is high, decreases the generation of side reaction and by product, reduces reactivity hazard and cost. |
| priorityDate | 2013-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.