| abstract |
Disclosed are cytotoxic conjugates comprising a cell-binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugates, methods of using the conjugates to inhibit cell growth and treat disease, and cytotoxic conjugates comprising the same reagent kits. In particular, cell-binding agents are monoclonal antibodies and epitope-binding fragments thereof, which recognize and bind CA6 carbohydrate epitopes. The invention also relates to humanized or resurfaced forms of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof. |