http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103145698-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 |
| filingDate | 2013-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103145698-B |
| titleOfInvention | A kind of preparation method of Rivaroxaban intermediate and the novel synthesis of razaxaban |
| abstract | The invention discloses a kind of preparation method of (S)-N-Racemic glycidol phthalic imidine of structural formula 1, comprise the steps: the phthalic imidine salt of I. structural formula 9 and compound heating reflux reaction in alcoholic solvent of structural formula 10, obtain the compound of structural formula 11; II. in aprotic solvent, the compound of the structural formula 11 that described step I obtains reacts with the compound of structural formula 12 under the effect of alkali, obtains (S)-N-Racemic glycidol phthalic imidine crude product of structural formula 1; III. (S)-N-Racemic glycidol phthalic imidine crude product of structural formula 1 of obtaining of Step II, refines with ethanol, obtains (S)-N-Racemic glycidol phthalic imidine of optical purity >=99.0%.Aforesaid method is simple to operate, and security is good, and products therefrom optical purity high (>=99.0%), is suitable for suitability for industrialized production.The present invention also discloses a kind of novel synthesis of razaxaban. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108546265-A |
| priorityDate | 2013-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.